1,048 research outputs found
Bio-inspired Tensegrity Soft Modular Robots
In this paper, we introduce a design principle to develop novel soft modular
robots based on tensegrity structures and inspired by the cytoskeleton of
living cells. We describe a novel strategy to realize tensegrity structures
using planar manufacturing techniques, such as 3D printing. We use this
strategy to develop icosahedron tensegrity structures with programmable
variable stiffness that can deform in a three-dimensional space. We also
describe a tendon-driven contraction mechanism to actively control the
deformation of the tensegrity mod-ules. Finally, we validate the approach in a
modular locomotory worm as a proof of concept.Comment: 12 pages, 7 figures, submitted to Living Machine conference 201
Kinetics of a mixed spin-1/2 and spin-3/2 Ising ferrimagnetic model
We present a study, within a mean-field approach, of the kinetics of a mixed
ferrimagnetic model on a square lattice in which two interpenetrating square
sublattices have spins that can take two values, , alternated
with spins that can take the four values, . We use the
Glauber-type stochastic dynamics to describe the time evolution of the system
with a crystal-field interaction in the presence of a time-dependent
oscillating external magnetic field. The nature (continuous and discontinuous)
of transition is characterized by studying the thermal behaviors of average
order parameters in a period. The dynamic phase transition points are obtained
and the phase diagrams are presented in the reduced magnetic field amplitude
and reduced temperature plane, and in the reduced temperature and
interaction parameter planes, namely in the and planes,
is the reduced crystal-field interaction. The phase diagrams always exhibit a
tricritical point in plane, but do not exhibit in the plane
for low values of . The dynamic multicritical point or dynamic critical end
point exist in the plane for low values of . Moreover, phase
diagrams contain paramagnetic , ferromagnetic , ferrimagnetic
phases, two coexistence or mixed phase regions, and , that
strongly depend on interaction parameters.Comment: 13 pages, 6 figures, submitted to Journal of Magnetism and Magnetic
Material
Weakened magnetic braking as the origin of anomalously rapid rotation in old field stars
A knowledge of stellar ages is crucial for our understanding of many
astrophysical phenomena, and yet ages can be difficult to determine. As they
become older, stars lose mass and angular momentum, resulting in an observed
slowdown in surface rotation. The technique of 'gyrochronology' uses the
rotation period of a star to calculate its age. However, stars of known age
must be used for calibration, and, until recently, the approach was untested
for old stars (older than 1 gigayear, Gyr). Rotation periods are now known for
stars in an open cluster of intermediate age (NGC 6819; 2.5 Gyr old), and for
old field stars whose ages have been determined with asteroseismology. The data
for the cluster agree with previous period-age relations, but these relations
fail to describe the asteroseismic sample. Here we report stellar evolutionary
modelling, and confirm the presence of unexpectedly rapid rotation in stars
that are more evolved than the Sun. We demonstrate that models that incorporate
dramatically weakened magnetic braking for old stars can---unlike existing
models---reproduce both the asteroseismic and the cluster data. Our findings
might suggest a fundamental change in the nature of ageing stellar dynamos,
with the Sun being close to the critical transition to much weaker magnetized
winds. This weakened braking limits the diagnostic power of gyrochronology for
those stars that are more than halfway through their main-sequence lifetimes.Comment: 25 pages, 3 figures in main paper, 6 extended data figures, 1 table.
Published in Nature, January 2016. Please see https://youtu.be/O6HzYgP5uyc
for a video description of the resul
Searching for plasticity in dissociated cortical cultures on multi-electrode arrays
We attempted to induce functional plasticity in dense cultures of cortical cells using stimulation through extracellular electrodes embedded in the culture dish substrate (multi-electrode arrays, or MEAs). We looked for plasticity expressed in changes in spontaneous burst patterns, and in array-wide response patterns to electrical stimuli, following several induction protocols related to those used in the literature, as well as some novel ones. Experiments were performed with spontaneous culture-wide bursting suppressed by either distributed electrical stimulation or by elevated extracellular magnesium concentrations as well as with spontaneous bursting untreated. Changes concomitant with induction were no larger in magnitude than changes that occurred spontaneously, except in one novel protocol in which spontaneous bursts were quieted using distributed electrical stimulation
Development of Photonic Crystal Fiber Based Gas/ Chemical Sensors
The development of highly-sensitive and miniaturized sensors that capable of
real-time analytes detection is highly desirable. Nowadays, toxic or colorless
gas detection, air pollution monitoring, harmful chemical, pressure, strain,
humidity, and temperature sensors based on photonic crystal fiber (PCF) are
increasing rapidly due to its compact structure, fast response and efficient
light controlling capabilities. The propagating light through the PCF can be
controlled by varying the structural parameters and core-cladding materials, as
a result, evanescent field can be enhanced significantly which is the main
component of the PCF based gas/chemical sensors. The aim of this chapter is to
(1) describe the principle operation of PCF based gas/ chemical sensors, (2)
discuss the important PCF properties for optical sensors, (3) extensively
discuss the different types of microstructured optical fiber based gas/
chemical sensors, (4) study the effects of different core-cladding shapes, and
fiber background materials on sensing performance, and (5) highlight the main
challenges of PCF based gas/ chemical sensors and possible solutions
Effectiveness and cost-effectiveness of an educational intervention for practice teams to deliver problem focused therapy for insomnia: rationale and design of a pilot cluster randomised trial
Background: Sleep problems are common, affecting over a third of adults in the United Kingdom and leading to reduced productivity and impaired health-related quality of life. Many of those whose lives are affected seek medical help from primary care. Drug treatment is ineffective long term. Psychological methods for managing sleep problems, including cognitive behavioural therapy for insomnia (CBTi) have been shown to be effective and cost effective but have not been widely implemented or evaluated in a general practice setting where they are most likely to be needed and
most appropriately delivered. This paper outlines the protocol for a pilot study designed to
evaluate the effectiveness and cost-effectiveness of an educational intervention for general practitioners, primary care nurses and other members of the primary care team to deliver problem focused therapy to adult patients presenting with sleep problems due to lifestyle causes, pain or mild to moderate depression or anxiety.
Methods and design: This will be a pilot cluster randomised controlled trial of a complex intervention. General practices will be randomised to an educational intervention for problem focused therapy which includes a consultation approach comprising careful assessment (using assessment of secondary causes, sleep diaries and severity) and use of modified CBTi for insomnia in the consultation compared with usual care (general advice on sleep hygiene and pharmacotherapy with hypnotic drugs). Clinicians randomised to the intervention will receive an educational intervention (2 Ă 2 hours) to implement a complex intervention of problem focused therapy. Clinicians randomised to the control group will receive reinforcement of usual care with sleep hygiene advice. Outcomes will be assessed via self-completion questionnaires and telephone
interviews of patients and staff as well as clinical records for interventions and prescribing.
Discussion: Previous studies in adults have shown that psychological treatments for insomnia administered by specialist nurses to groups of patients can be effective within a primary care setting. This will be a pilot study to determine whether an educational intervention aimed at primary care teams to deliver problem focused therapy for insomnia can improve sleep management and outcomes for individual adult patients presenting to general practice. The study will also test procedures and collect information in preparation for a larger definitive cluster-randomised trial. The study is funded by The Health Foundation
Maternal obesity support services: a qualitative study of the perspectives of women and midwives
Background -
Twenty percent of pregnant women in the UK are obese (BMI â„ 30 kg/m2), reflecting the growing public health challenge of obesity in the 21st century. Obesity increases the risk of adverse outcomes during pregnancy and birth and has significant cost implications for maternity services. Gestational weight management strategies are a high priority; however the evidence for effective, feasible and acceptable weight control interventions is limited and inconclusive. This qualitative study explored the experiences and perceptions of pregnant women and midwives regarding existing support for weight management in pregnancy and their ideas for service development.
Methods -
A purposive sample of 6 women and 7 midwives from Doncaster, UK, participated in two separate focus groups. Transcripts were analysed thematically.
Results -
Two overarching themes were identified, 'Explanations for obesity and weight management' and 'Best care for pregnant women'. 'Explanations' included a lack of knowledge about weight, diet and exercise during pregnancy; self-talk messages which excused overeating; difficulties maintaining motivation for a healthy lifestyle; the importance of social support; stigmatisation; and sensitivity surrounding communication about obesity between midwives and their clients. 'Best care' suggested that weight management required care which was consistent and continuous, supportive and non-judgemental, and which created opportunities for interaction and mutual support between obese pregnant women.
Conclusions -
Women need unambiguous advice regarding healthy lifestyles, diet and exercise in pregnancy to address a lack of knowledge and a tendency towards unhelpful self-talk messages. Midwives expressed difficulties in communicating with their clients about their weight, given awareness that obesity is a sensitive and potentially stigmatising issue. This indicates more could be done to educate and support them in their work with obese pregnant women. Motivation and social support were strong explanatory themes for obesity and weight management, suggesting that interventions should focus on motivational strategies and social support facilitation
Electrically controlled long-distance spin transport through an antiferromagnetic insulator
Spintronics uses spins, the intrinsic angular momentum of electrons, as an
alternative for the electron charge. Its long-term goal is in the development
of beyond-Moore low dissipation technology devices. Recent progress
demonstrated the long-distance transport of spin signals across ferromagnetic
insulators. Antiferromagnetically ordered materials are however the most common
class of magnetic materials with several crucial advantages over ferromagnetic
systems. In contrast to the latter, antiferromagnets exhibit no net magnetic
moment, which renders them stable and impervious to external fields. In
addition, they can be operated at THz frequencies. While fundamentally their
properties bode well for spin transport, previous indirect observations
indicate that spin transmission through antiferromagnets is limited to short
distances of a few nanometers. Here we demonstrate the long-distance, over tens
of micrometers, propagation of spin currents through hematite (\alpha-Fe2O3),
the most common antiferromagnetic iron oxide, exploiting the spin Hall effect
for spin injection. We control the spin current flow by the interfacial
spin-bias and by tuning the antiferromagnetic resonance frequency with an
external magnetic field. This simple antiferromagnetic insulator is shown to
convey spin information parallel to the compensated moment (N\'eel order) over
distances exceeding tens of micrometers. This newly-discovered mechanism
transports spin as efficiently as the net magnetic moments in the best-suited
complex ferromagnets. Our results pave the way to ultra-fast, low-power
antiferromagnet-insulator-based spin-logic devices that operate at room
temperature and in the absence of magnetic fields
EZH2 Codon 641 Mutations are Common in BCL2-Rearranged Germinal Center B Cell Lymphomas
Mutations at codon 641 of EZH2 are recurrent in germinal center B cell lymphomas, and the most common variants lead to altered EZH2 enzymatic activity and enhanced tri-methylation of histone H3 at lysine 27, a repressive chromatin modification. As an initial step toward screening patients for cancer genotype-directed therapy, we developed a screening assay for EZH2 codon 641 mutations amenable for testing formalin-fixed clinical specimens, based on the sensitive SNaPshot single nucleotide extension technology. We detected EZH2 mutations in 12/55 (22%) follicular lymphomas (FL), 5/35 (14%) diffuse large B cell lymphomas with a germinal center immunophenotype (GCB-DLBCL), and 2/11 (18%) high grade B cell lymphomas with concurrent rearrangements of BCL2 and MYC. No EZH2 mutations were detected in cases of Burkitt lymphoma (0/23). EZH2 mutations were frequently associated with the presence of BCL2 rearrangement (BCL2-R) in both the FL (28% of BCL-R cases versus 0% of BCL2-WT cases, p<0.05) and GCB-DLBCL groups (33% of BCL2-R cases versus 4% of BCL2-WT cases, p<0.04), and across all lymphoma types excluding BL (27% of BCL2-R cases versus 3% of BCL2-WT cases, p<0.003). We confirmed gain-of-function activity for all previously reported EZH2 codon 641 mutation variants. Our findings suggest that EZH2 mutations constitute an additional genetic âhitâ in many BCL2-rearranged germinal center B cell lymphomas. Our work may be helpful in the selection of lymphoma patients for future trials of pharmacologic agents targeting EZH2 and EZH2-regulated pathways
Radio Emission from Ultra-Cool Dwarfs
The 2001 discovery of radio emission from ultra-cool dwarfs (UCDs), the very
low-mass stars and brown dwarfs with spectral types of ~M7 and later, revealed
that these objects can generate and dissipate powerful magnetic fields. Radio
observations provide unparalleled insight into UCD magnetism: detections extend
to brown dwarfs with temperatures <1000 K, where no other observational probes
are effective. The data reveal that UCDs can generate strong (kG) fields,
sometimes with a stable dipolar structure; that they can produce and retain
nonthermal plasmas with electron acceleration extending to MeV energies; and
that they can drive auroral current systems resulting in significant
atmospheric energy deposition and powerful, coherent radio bursts. Still to be
understood are the underlying dynamo processes, the precise means by which
particles are accelerated around these objects, the observed diversity of
magnetic phenomenologies, and how all of these factors change as the mass of
the central object approaches that of Jupiter. The answers to these questions
are doubly important because UCDs are both potential exoplanet hosts, as in the
TRAPPIST-1 system, and analogues of extrasolar giant planets themselves.Comment: 19 pages; submitted chapter to the Handbook of Exoplanets, eds. Hans
J. Deeg and Juan Antonio Belmonte (Springer-Verlag
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